Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
نویسندگان
چکیده
منابع مشابه
Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, capsules, and syrups for being patient friendly. Buccal films are one such system responsible for systemic drug delivery at the desired site of action by avoiding hepatic first-pass metabolism. Metformin hydrochloride (Met), an antidiabetic drug, has poor bioavailabil...
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Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it sh...
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Promethazine hydrochloride, a 5-HT3 antagonist is a powerful antiemetic drug with an oral bioavailability of 25% due to extensive hepatic first pass metabolism and is extremely bitter in taste. To overcome the above draw backs, the present study was carried out to formulate and evaluate fast dissolving taste masked wafers of Promethazine hydrochloride for sublingual administration. Taste maskin...
متن کاملFormulation & Evaluation of Fast dissolving Buccal films of Sertraline
The hydrochloride of Sertraline is a white crystalline powder; slightly soluble in water and freely soluble in ethanol [1]. It is a drug of selective serotonin reuptake inhibitors (SSRI) that is chemically unrelated to other SSRIs, tricyclic, tetracyclic, or other available antidepressant drugs. Sertraline inhibit the inactivation of serotonin (5hydroxytryptamine or 5-HT) by blocking its absorp...
متن کاملFormulation, Development & Evaluation of Oral Fast Dissolving Anti-Allergic Film of Levocetrizine Dihydrochloride
Fast dissolving film of levocetrizine dihydrochloride were prepared by solvent casting method by using Maltodextrin & HPMC E15 as the main film forming polymers.To decrease the disintegration time,concentration of maltodextrin & HPMC E15 were optimized be using 2 factorial design. Disintegration time, drug release pattern, mouth dissolving time and content uniformity were also evaluated. Compat...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2015
ISSN: 1178-2013
DOI: 10.2147/ijn.s80052